Apidra is a rapid-acting insulin commonly used for mealtime control of blood sugar.

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What is it?

Apidra contains insulin glulisine, a rapid-acting insulin analog. Insulin analogs are man-made versions of the naturally occurring insulin. Apridra is a type of rapid-acting insulin that is available in the bloodstream earlier than human insulin. Rapid-acting insulins such as Apidra are commonly used in combination with long-acting insulins.

What is it used for?

Apidra is used to treat type 1 or type 2 diabetes in adults, and type 1 diabetes children who are at least 4 years old.

How does it work?

Insulin glulisine differs from human insulin in that the amino acid asparagine in position B3 is replaced by lysine and the lysine in position B29 is replaced by glutamic acid. As a result of these changes, insulin glulisine is availabe in the blood stream more quickly after injection than human insulin.


Unopened vials and pens should be stored in a refrigerator, 36°F-46°F (2°C-8°C). In-use insulin can be kept at room temperature (below 86°F), away from direct heat and light. Insulin should not be stored in the freezer, and it should not be allowed to freeze. Discard if it has been frozen.


Apidra is contraindicated in patients who have had hypersensitivity reactions to insulin glulisine or one of the excipients.

Drug interactions

You should speak to your healthcare provider if you take one of the following medications: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics, GLP-1 receptor agonists, DPP-4 inhibitors, SGLT-2 inhibitors, atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), thyroid hormones, alcohol, beta-blockers, clonidine, lithium salts, pentamidine, guanethidine, and reserpine.

Additional information

100 units/mL


3 mL Pens (Box of 5), 10 mL Vial, 3 mL Cartridges (Box of 5)