Humalog 75/25


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What is it?

Humalog 75/25 is a mixture of 75% insulin lispro protamine and 25% insulin lispro. Insulin lispro protamine is an intermediate-acting insulin, while insulin lispro is a rapid-acting insulin. The combination of insulin lisproprotamine and insulin lispro in Humalog 75/25 allows it to start working as quickly as rapid-acting insulin, but last longer.

What is it used for?

Humalog is used to improve glycemic control in patients with diabetes mellitus.

How does it work?

Humalog 75/25 contains both an intermediate-acting insulin (insulin lispro protamine) and a rapid-acting insulin (insulin lispro). The intermediate insulin provides continued coverage and the rapid-acting insulin decreases blood sugar in the short term.


Unopened vials and pens should be stored in a refrigerator, 36°F-46°F (2°C-8°C). In-use insulin can be kept at room temperature (below 86°F), away from direct heat and light. Insulin should not be stored in the freezer, and it should not be allowed to freeze. Discard if it has been frozen.


Humalog 75/25 is contraindicated in patients who have had hypersensitivity reactions to insulin lispro, insulin lispro protamine, or one of the excipients.

Drug interactions

You should speak to your healthcare provider if you take one of the following medications: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics, GLP-1 receptor agonists, DPP-4 inhibitors, SGLT-2 inhibitors, atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), thyroid hormones, alcohol, beta-blockers, clonidine, lithium salts, pentamidine, guanethidine, and reserpine.

Additional information

3 mL Pens (Box of 5), 3 mL Cartridges (Box of 5)