Humalog is a rapid-acting insulin commonly used for mealtime control of blood sugar.

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What is it?

Humalog contains insulin lispro, a rapid-acting insulin analog. Insulin analogs are man-made versions of the naturally occurring insulin. Humalog is a type of rapid-acting insulin that is available in the bloodstream earlier than human insulin. Rapid-acting insulins such as Humalog are commonly used in combination with long-acting insulins.

What is it used for?

Humalog is used to improve glycemic control in adults and children with diabetes mellitus.

How does it work?

Insulin lispro differs from human insulin in that the final lysine and proline residues on the C-terminal end of the B-chain are reversed. This blocks the formation of insulin dimers and hexamers, allowing larger amounts of active insulin to be immediately available.


Unopened vials and pens should be stored in a refrigerator, 36°F-46°F (2°C-8°C). In-use insulin can be kept at room temperature (below 86°F), away from direct heat and light. Insulin should not be stored in the freezer, and it should not be allowed to freeze. Discard if it has been frozen.


Humalog is contraindicated in patients who have had hypersensitivity reactions to insulin lispro or one of the excipients.

Drug interactions

You should speak to your healthcare provider if you take one of the following medications: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics, GLP-1 receptor agonists, DPP-4 inhibitors, SGLT-2 inhibitors, atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), thyroid hormones, alcohol, beta-blockers, clonidine, lithium salts, pentamidine, guanethidine, and reserpine.

Additional information

3 mL KwikPens (Box of 5) – 100 units/mL, 3 mL KwikPens (Box of 5) – 200 units/mL, 10 mL Vial