Humulin 50/50

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What is it?

Humulin 50/50 is a mixture of 50% insulin isophane (NPH) and 50% regular insulin. NPH (insulin isophane) is an intermediate-acting insulin, while regular insulin has the same timing of response as insulin produced by the human body. The combination of NPH and regular insulin in Humulin 50/50 allows it to start working as quickly as regular insulin, but last longer.

What is it used for?

Humulin 50/50 is used to improve blood sugar control in adults with diabetes mellitus.

How does it work?

Humulin 50/50 contains both a short-acting insulin (regular insulin) and an intermediate-acting insulin (insulin NPH). The regular insulin decreases blood sugar in the short term, and the intermediate insulin provides continued coverage.


Unopened vials and pens should be stored in a refrigerator, 36°F-46°F (2°C-8°C). In-use insulin can be kept at room temperature (below 86°F), away from direct heat and light. Insulin should not be stored in the freezer, and it should not be allowed to freeze. Discard if it has been frozen.


Humulin 50/50 is contraindicated in patients who have had hypersensitivity reactions to regular insulin, insulin isophane (NPH), or one of the excipients.

Drug interactions

You should speak to your healthcare provider if you take one of the following medications: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics, GLP-1 receptor agonists, DPP-4 inhibitors, SGLT-2 inhibitors, atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), thyroid hormones, alcohol, beta-blockers, clonidine, lithium salts, pentamidine, guanethidine, and reserpine.