What is it?
Humulin N contains regular insulin combined with protamine, resulting in small crystals that slowly release the insulin after injection. This results in longer lasting glycemic control relative to regular insulin.
What is it used for?
Humulin N is used to improve glycemic control in adults and pediatric patients with diabetes mellitus.
How does it work?
Insulin NPH is made by combining insulin with protamine, which forms small crystals. When this is injected, the regular insulin is slowly relased, providing long lasting glycemic control.
Unopened vials and pens should be stored in a refrigerator, 36°F-46°F (2°C-8°C). In-use insulin can be kept at room temperature (below 86°F), away from direct heat and light. Insulin should not be stored in the freezer, and it should not be allowed to freeze. Discard if it has been frozen.
Humulin N is contraindicated in patients who have had hypersensitivity reactions to regular insulin, insulin isophane (NPH), or one of the excipients.
You should speak to your healthcare provider if you take one of the following medications: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics, GLP-1 receptor agonists, DPP-4 inhibitors, SGLT-2 inhibitors, atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), thyroid hormones, alcohol, beta-blockers, clonidine, lithium salts, pentamidine, guanethidine, and reserpine.