What is it?
Lantus contains insulin glargine, a long-acting insulin analog. Insulin analogs are man-made versions of the naturally occurring insulin. Lantus is a type of baseline insulin that is slowly released, resulting in a long duration of action. Long-acting, baseline insulins such as Lantus are commonly used in combination with short- or rapid-acting insulins, with the short- or rapid-acting insulin being used around meals.
What is it used for?
Lantus is used to improve glycemic control in adults and pediatric patients with type 1 diabetes mellitus and in adults with type 2 diabetes mellitus.
How does it work?
Insulin glargine differs from human insulin in that the amino acid asparagine in position A21 has been replaced by glycine and by carboxy-terminal extension of B-chain by 2 arginine residues. As a result of this change, insulin glargine forms micro-crystals when injected subcutaneously. This depot of insulin results in slow insulin release into the systemic circulation.
Unopened vials and pens should be stored in a refrigerator, 36°F-46°F (2°C-8°C). In-use insulin can be kept at room temperature (below 86°F), away from direct heat and light. Insulin should not be stored in the freezer, and it should not be allowed to freeze. Discard if it has been frozen.
Lantus is not recommended for treatment of diabetic ketoacidosis (DKA). Lantus is contraindicated in patients who have had hypersensitivity reactions to insulin glargine or one of the excipients.
You should speak to your healthcare provider if you take one of the following medications: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics, GLP-1 receptor agonists, DPP-4 inhibitors, SGLT-2 inhibitors, atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), thyroid hormones, alcohol, beta-blockers, clonidine, lithium salts, pentamidine, guanethidine, and reserpine.