What is it?
Levemir contains insulin detemir, a long-acting insulin analog. Insulin analogs are man-made versions of the naturally occurring insulin. Levemir is a type of baseline insulin that is slowly released, resulting in a long duration of action. Long-acting, baseline insulins such as Levemir are commonly used in combination with short- or rapid-acting insulins, with the short- or rapid-acting insulin being used around meals.
What is it used for?
Levemir is used to improve glycemic control in adults and children with diabetes mellitus.
How does it work?
Insulin detemir differs from human insulin in that the amino acid lysine in position B29 has myristic acid bound to it. As a result of this change, insulin detemir binds to albumin in the blood and is slowly released.
Unopened vials and pens should be stored in a refrigerator, 36°F-46°F (2°C-8°C). In-use insulin can be kept at room temperature (below 86°F), away from direct heat and light. Insulin should not be stored in the freezer, and it should not be allowed to freeze. Discard if it has been frozen.
Levemir is not recommended for treatment of diabetic ketoacidosis (DKA). Levemir is contraindicated in patients who have had hypersensitivity reactions to insulin detemir or one of the excipients.
You should speak to your healthcare provider if you take one of the following medications: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics, GLP-1 receptor agonists, DPP-4 inhibitors, SGLT-2 inhibitors, atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), thyroid hormones, alcohol, beta-blockers, clonidine, lithium salts, pentamidine, guanethidine, and reserpine.