Novolog 70/30


Box of 5 Pens (3mL each)

Novolog 70/30 is a premixed insulin that combines NPH (insulin isophane) and fast-acting insulin (insulin aspart) to control blood sugar. It is the same insulin rebranded as Novomix 30 in Canada.

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What is it?

Novolog 70/30 is a mixture of 70% insulin aspart protamine and 30% insulin aspart. Insulin aspart protamine is an intermediate-acting insulin, while insulin aspart is a rapid-acting insulin. The combination of Insulin aspart protamine and insulin aspart in Novolog 70/30 allows it to start working quickly, but last longer that rapid-acting insulin alone.

What is it used for?

Novolog 70/30 is used to improve blood sugar control in adults with diabetes mellitus.

How does it work?

Novolog 70/30 contains both a short-acting insulin (insulin aspart) and an intermediate-acting insulin (insulin aspart protamine). The insulin aspart decreases blood sugar in the short term, and the insulin aspart protamine provides continued coverage.


Unopened vials and pens should be stored in a refrigerator, 36°F-46°F (2°C-8°C). In-use insulin can be kept at room temperature (below 86°F), away from direct heat and light. Insulin should not be stored in the freezer, and it should not be allowed to freeze. Discard if it has been frozen.


Novolog 70/30 is not recommended for treatment of diabetic ketoacidosis (DKA). Novolog 70/30 is contraindicated in patients who have had hypersensitivity reactions to insulin aspart, insulin aspart protamine, or one of the excipients.

Drug interactions

You should speak to your healthcare provider if you take one of the following medications: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics, GLP-1 receptor agonists, DPP-4 inhibitors, SGLT-2 inhibitors, atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), thyroid hormones, alcohol, beta-blockers, clonidine, lithium salts, pentamidine, guanethidine, and reserpine.