Tresiba is a long-acting insulin commonly used for baseline control of blood sugar.

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What is it?

Tresiba contains insulin degludec, a long-acting insulin analog. Insulin analogs are man-made versions of the naturally occurring insulin. Tresiba is a type of baseline insulin that is slowly released, resulting in a long duration of action. Long-acting, baseline insulins such as Tresiba are commonly used in combination with short- or rapid-acting insulins, with the short- or rapid-acting insulin being used around meals.

What is it used for?

Tresiba is used to improve glycemic control in patients 1 year of age and older with diabetes mellitus.

How does it work?

Insulin degludec differs from human insulin in that the amino acid threonine in position B30 has been omitted and a side-chain consisting of glutamic acid and a C16 fatty acid has been attached (chemical name: LysB29(Nε-hexadecandioyl-γ-Glu) des(B30) human insulin). As a result of this change, insulin degludec forms multi-hexamers when injected subcutaneously. This depot of insulin results in slow insulin release into the systemic circulation.


Unopened vials and pens should be stored in a refrigerator, 36°F-46°F (2°C-8°C). In-use insulin can be kept at room temperature (below 86°F), away from direct heat and light. Insulin should not be stored in the freezer, and it should not be allowed to freeze. Discard if it has been frozen.


Tresiba is not recommended for treatment of diabetic ketoacidosis (DKA). Tresiba is contraindicated in patients who have had hypersensitivity reactions to insulin degludec or one of the excipients.

Drug interactions

You should speak to your healthcare provider if you take one of the following medications: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics, GLP-1 receptor agonists, DPP-4 inhibitors, SGLT-2 inhibitors, atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), thyroid hormones, alcohol, beta-blockers, clonidine, lithium salts, pentamidine, guanethidine, and reserpine.

Additional information

3mL Pens – 200 Units/mL (Box of 3), 3mL Pen – 100 Units/mL (Box of 5)